Robert Koch was a German physician who specialized in microbiology. He was fascinated by the microbial world and devoted much of his work toward it. He discovered the cause of
Anthrax,
Cholera, and
Tuberculosis. Between 1884 and 1890, Koch and his colleagues formulated and published a set of
postulates, or rules, by which a bacteria could be definitively identified as the cause of a disease. These rules are the basis on which scientists today establish whether or not certain bacteria (or viruses, in some cases) cause a disease. The rules are:
1. The organism (bacteria) must be isolated from every case. For example, if then people walk in with tuberculosis, all ten of them should have the same bacteria infecting their lungs.
2. The organism must be isolated and cultured in the lab. For example, the bacteria in all ten people with tuberculosis must be placed on a plate and grown in the lab, with no other bacteria growing with it.
3. If a healthy individual is exposed to the lab-grown bacteria, the individual must develop the disease. For the sake of medical ethics, let's say that a lab tech had an accident and was exposed to the bacteria isolated from the ten cases of tuberculosis. The lab tech should then develop tuberculosis.
4. The organism must be isolated from the infected "test" subject.
They may look like simple rules, and they sometimes are, but some bacteria and viruses are hard to grow in the lab. This is because different strains of bacteria and viruses have different needs when it comes to growing them in the lab. Some need more or less oxygen, some need more or less carbohydrates, etc. Applying Koch's postulates to new diseases is difficult to do when you're dealing with something totally new, like SARS early this decade, or HIV back in the 1980's. So scientists have developed
their own guidelines for establishing cause and effect when it comes to diseases, yet these guidelines are still based on Koch's postulates.
Imagine that a group of ten children in a school of 100 students develop a type of cancer that is only seen in 1 in a 100,000 people in the rest of the population. As the State epidemiologist, people are demanding answers from you because they are sure that something at the school is causing the disease. You would start by interviewing the children and their parents. Environmental testing of the school would probably be the second step. If the children all belong to the same after school activity group(s), the environment where they all gather would also be tested for known carcinogens. Sometimes an all-out response is warranted (many times by political pressures), so the food the children eat, the water they drink, and the air they breathe together or independently would get tested. If a theory about the source of their disease is developed, it gets tested. Testing that theory involves Koch's postulates:
1. All the sick children must have been exposed to the theoretical source of the disease. A group of non-sick children (called "controls") must have not been exposed. Exposure can be identified by lab tests or simple questions about their habits.
2. The theoretical source of the disease must have been shown to cause the disease in a controlled laboratory setting. In other words, it must be a known carcinogen. This is a sore point in some cases because special interest groups will either protect or accuse chemicals and materials as being carcinogens. For example, the
tobacco industry invested millions of dollars to defend
cigarettes as sources of lung cancer. Also, some consumer groups are convinced that
cellular phones cause cancer.
3. Someone who was absolutely healthy to begin with, upon being exposed to the theoretical cause, develops the exact same cancer. This can be tested by knowing exactly when any of the cases was exposed or by knowing exactly if and when someone in the population was exposed and then developed the cancer.
4. The suspected cause must be found to have been in the "test" case. Lab work or a simple interview helps in this.
As you can see, it can be difficult to go through the 4 steps of the investigation and come to a definitive conclusion. Even if a definitive cause is proven, the source of the cause might not be. That can be frustrating too, and this is often the case with environmental health issues. If the cause is found all over the environment, are health authorities sure that it wasn't "masking" the real cause?
Unfortunately, many of the ideas about the causes of disease that reach the public airwaves and the internet are not supported by any kind of systematic testing of the theory:
1.
Vaccines cause autism. Not all people with autism received vaccines AND not all people who receive vaccines become autistic. So vaccines are not necessary nor sufficient to cause autism. Hence the need for more research into the true cause. Perhaps it is genetic, where certain genetic profiles lead people to react differently to the vaccines' components? Perhaps vaccines are so universal that the true cause is being "masked". What if it is some sort of bacteria exclusively found in cotton balls used to clean the skin before a vaccine? What if?
2.
Power lines cause brain tumors. Again, not all people who live under the power lines develop brain tumors, and not all who have brain tumors lived near power lines. Is there something about the homes and/or lifestyle of those who live near power lines that places them at particular risk?
Entire textbooks have been written on the other diseases and conditions attributable to the
government,
secret societies,
big enterprises, multinational corporations, etc, etc. However, knowing the four steps established by Dr. Koch, and analyzing the evidence in light of them can help make better decisions at the personal and policy level.